The United Nations (UN) has proclaimed 2021-2030 the Decade of Healthy Ageing, with the World Health Organization (WHO) leading international actions to improve the well-being of older people. WHO has embraced a more holistic definition of well-being, given the interaction between physical health, mental health, and environmental factors, it has declared that there is no health without mental health. However, physical health, mental health, and environmental factors had seldomly been discussed all at once, especially when it comes to the overall well-being of older adults. The Symposium brings together world-renowned speakers to share the cutting-edge multidisciplinary research findings based on the framework of healthy aging, and discuss the implications of this framework for decision-makers, researchers, and practitioners.